Synthesis of thio-Pyrimidine, Benzoxazole, Benzothiazole and Triazole Analogues from Baylis-Hillman Bromides as Potent Cyclooxygenase-2 Inhibitors
نویسنده
چکیده
Non-steroidal anti-inflammatory drugs play a major role in pain management. This article discusses the synthesis of thio-Pyrimidine, Benzoxazole, Benzothiazole and Triazole Analogues from Baylis-Hillman Bromides and their in-vitro testing for the activity of cyclooxygenase (COX) inhibition. The results are very encouraging and we can proceed for further investigations regarding their safety, in-vivo issues etc.
منابع مشابه
Rapid and Green Synthesis of some Benzothiazole-, Benzimidazole- and Benzoxazole-2-thiol Derivatives Using Copper Sulfate in Aqueous Media
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